Under the Chemical Substances Control Law (CSCL), enterprises shall report new chemical substances based on their annual production or import volume.

MOE proposes designating NPE as Class II Specified Chemical Substances to strengthen control over its production, import, and use.

On November 28, 2023, Japan's Ministry of Health, Labor and Welfare, Ministry of Economy, Trade and Industry and Ministry of Environment jointly announced that the cabinet has approved the partial amendment to the Chemical Substance Control Law (CSCL).

On November 8, 2023, the Ministry of Health, Labor, and Welfare, the Ministry of Economy, Trade and Industry, and the Ministry of the Environment jointly published the public consultation results for its revision to the Chemical Substance Control Law (CSCL), which started on September 15. The consultation drew extensive attention and various suggestions were submitted.