14 Substance Testing Proposals Under REACH Registration to be Approved

On March 17, 2025, the European Chemicals Agency (ECHA) announced the addition of 14 new substance testing proposals and invited public comments by May 2. ECHA’s public consultation on testing proposals is part of an open evaluation process to determine whether additional testing is required for registered chemicals.

Under the REACH Regulation, before conducting tests listed in Annex IX and X (corresponding to registration tonnage bands of 100–1,000 tonnes per year and over 1,000 tonnes per year), registrants must submit a testing proposal (TP). After the consultation period, ECHA will finalize the testing requirements based on feedback and the specific properties of the substances.

By gathering public input, ECHA aims to optimize safety assessments and revise testing requirements to align with stakeholder feedback. Registrants must carry out these tests and update their safety dossiers to ensure the safe use of chemicals and promote sustainable development in the industry.

Name	EC Number	CAS Number	Deadline for submitting information	Hazard endpoint for which vertebrate testing was proposed
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione	254-996-9	40601-76-1	02/05/2025	5.3.1 Bioaccumulation aquatic / sediment
4-methylpentan-2-ol	203-551-7	108-11-2	02/05/2025	6.1.2 Long-term toxicity to fish\|\|Note: testing proposed with 4-methylpentan-2-ol (EC no. 203-551-7) and with 4-methylpentan-2-one (EC no. 203-550-1) 7.5.1 Repeated dose toxicity: oral 7.8.1 Toxicity to reproduction 7.8.2 Developmental toxicity / teratogenicity
Alcohols, C12-14, ethoxylated	500-213-3	68439-50-9	02/05/2025	7.8.1 Toxicity to reproduction
C6 sugars residues concentrated extract from hardwood by steam explosion, acidic and enzymatic hydrolysis	955-928-7	-	02/05/2025	7.6.2 Genetic toxicity in vivo
D-Glucitol, -O-(oxiranylmethyl)-, -O-(3-chloro2-hydroxypropoxyl)- oligomers	957-604-0	-	02/05/2025	7.6.2 Genetic toxicity in vivo
Dioctyl phosphonate	217-315-6	1809-14-9	02/05/2025	6.1.2 Long-term toxicity to fish
Hexanedioic acid, 1,6-bis[2-hydroxy-3-[(1-oxoneodecyl)oxy]propyl] ester	825-846-5	876528-25-5	02/05/2025	7.5.1 Repeated dose toxicity: oral 7.6.2 Genetic toxicity in vivo 7.8.2 Developmental toxicity / teratogenicity
Reaction mass of cis-Cyclohexane, 1,4-bis(ethoxymethyl) and trans-Cyclohexane, 1,4-bis(ethoxymethyl)	700-868-7	54889-63-3	02/05/2025	7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity

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